Frequently Asked Questions

What information does the DecisionDx®-Melanoma test provide?

DecisionDx-Melanoma provides you and your healthcare professional with personalized information to help inform decisions about a sentinel lymph node biopsy (SLNB) surgical procedure and your follow-up management and care plan. The test identifies the likelihood that your tumor could recur or spread within the next 5 years. For most patients eligible for a sentinel lymph node biopsy, the test can also provide information to help make decisions about this surgical procedure.

This information should be helpful for you and your healthcare professional to decide on a treatment plan. Your care team will incorporate the DecisionDx-Melanoma results based on your individual situation, together with results from other tests and procedures.

How do I get a DecisionDx-Melanoma test?

Your healthcare professional (physician, physician assistant, or nurse practitioner) needs to order the test for you. The test can also be requested via an online portal.

How long does it take to get the results?

The laboratory will send a report with the test results to your healthcare professional within approximately 5 days after receiving the tumor sample in our laboratory.

Where is the test performed?

All of our tests are performed in our clinical laboratory located in Phoenix, Arizona. Our laboratory is Clinical Laboratory Improvement Act (CLIA)-certified and accredited by the College of American Pathologists (CAP). Our laboratory is licensed to perform tests throughout the United States.

Will my insurance cover the DecisionDx-Melanoma test?

Castle Biosciences will work on your behalf with all insurance providers, including Medicare, commercial insurance providers and, in some cases, the healthcare professional’s institution to secure payment coverage for the DecisionDx-Melanoma test. Castle submits insurance claims on your behalf, works with your healthcare professional’s office, and follows through to payment. Castle Biosciences believes a patient’s ability to pay for the test should not affect their care and therefore has put a generous Patient Assistance Program in place for those who need it.

What if my healthcare professional doesn’t offer the test?

Molecular diagnostic testing is an emerging, fast-growing field so your healthcare professional may not know about all of the tests that are now available. If your healthcare professional is interested in more information, please ask them to contact us at 866-788-9007.

Can I order a DecisionDx-Melanoma test as a patient?

No. Only healthcare professionals (physician, physician assistants, or nurse practitioner) can order a test from Castle Biosciences. If you need help finding a healthcare professional who can order the test for you, please contact our customer service team at 866-788-9007 or email us at

Who can I contact if I have a question?

Please call our customer service staff at 866-788-9007 or email us at

Learn How
Can Predict the Risk of Your Melanoma Recurring or Spreading


Download the Healthcare Professional Discussion Guide


What’s Next?

The Role of Genomic Testing

How Do You Get a
DecisionDx-Melanoma Test?